Hydrochloric Acid → HCID 18543276, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][CH2:10][C:11]#[N:12])[CH:5]=[C:6]([Cl:8])[CH:7]=1.O.Cl.[OH-].[Na+]>COCCOC>[Cl:8][C:6]1[CH:5]=[C:4]([S:9][CH2:10][CH2:11][NH2:12])[CH:3]=[C:2]([Cl:1])[CH:7]=1참가 물질
6
실험 절차
To a solution of (3,5-dichlorophenylthio)acetonitrile (1.2 g) in 3.0 mL of ethylene glycol dimethyl ether is added 0.61 mL of 10M borne dimethyl sulfide complex and the mixture heated at reflux for 0.5 hours. The reaction is cooled in an ice bath and 2.0 mL of water and 2.0 mL of concentrated hydrochloric acid is added. This mixture is heated at reflux for 0.5 hr. The clear solution is then cooled and basified with 5N sodium hydroxide and extracted with ether. The ether extract is dried over potassium carbonate, filtered and concentrated to give 1.0 g of a colorless oil.
후처리
- temperaturethe mixture heated
- temperatureat reflux for 0.5 hours
- temperatureThe reaction is cooled in an ice bath
- temperatureThis mixture is heated
- temperatureat reflux for 0.5 hr
- temperatureThe clear solution is then cooled
- extractionextracted with ether
- extractionThe ether extract
- dry with materialis dried over potassium carbonate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-d4ac9e3d476b4c87ac2e3f5770222e32
- 출처 데이터셋
- uspto-grants-2002_10
- 특허 번호
- US06462055B2
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