Hydrochloric Acid → HCID 9931407, 화합물

HRID 991427노트

반응식

HRID 991427 반응식
P(Cl)(Cl)(Cl)=O.[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:11]([OH:13])=O.[NH2:19][C:20]1[CH:21]=[C:22]([NH:27][C:28](=[O:35])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:23]=[CH:24][C:25]=1[Cl:26].Cl>N1C=CC=CC=1>[C:28]([NH:27][C:22]1[CH:23]=[CH:24][C:25]([Cl:26])=[C:20]([NH:19][C:11](=[O:13])[C:10]2[CH:14]=[CH:15][C:16]([O:17][CH3:18])=[C:8]([O:7][CH3:6])[CH:9]=2)[CH:21]=1)(=[O:35])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7121Veratric AcidHCID 24813Phosphorus oxychlorideHCID 16774920N-(3-Amino-4-chlorophenyl)benzamide

생성물 1

HCID 9931407HCID 9931407, 화합물수율 52.8%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
0 °C

실험 절차

Phosphoryl chloride (0.074 g) was added to a stirred mixture of 3,4-dimethoxybenzoic acid (0.088 g), N-(3-amino-4-chlorophenyl)benzamide (0.1 g) and pyridine (1 ml) which had been cooled to 0° C. The mixture was allowed to warm to ambient temperature and was stirred for 16 hours. The mixture was poured into 1N aqueous hydrochloric acid solution and the resultant solid was isolated, washed with a saturated aqueous sodium bicarbonate solution and dried under vacuum at 55° C. There was thus obtained the title compound (0.088 g);

후처리

  1. temperatureto warm to ambient temperature
  2. customthe resultant solid was isolated
  3. washwashed with a saturated aqueous sodium bicarbonate solution
  4. customdried under vacuum at 55° C

출처 및 근거

ORD 기록
ord-2ac77d2e7b0442e39f4501471b6d40e6
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06465455B1

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