Acetic Acid → 1-Nitroadamantane

반응식

[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH:11][N:12]1C(=O)C2=CC=CC=C2C1=O.C(O)(=[O:25])C>>[N+:12]([C:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2)([O-:11])=[O:25]

참가 물질

반응물 3

HCID 176Acetic Acid

HCID 9238Adamantane2회

HCID 10665N-Hydroxyphthalimide

생성물 1

HCID 641651-Nitroadamantane수율 64%

실험 절차

Into a flask, 1 mmole of adamantane, 0.1 mmole of N-hydroxyphthalimide and 6 ml of acetic acid were added to mix. The flask was purged by nitrogen monoxide NO (about 1L) and oxygen O2 (about 1L), and then the mixture was reacted for 20 hours at 110° C. with stirring. The reaction products were analyzed by gas chromatography, and, as a result, the conversion of adamantane was 90%, and 1-nitroadamantane (yield 64%) and 1,3-dinitroadamantane (yield 12%) were formed.

후처리

additionto mix
customThe flask was purged by nitrogen monoxide NO (about 1L) and oxygen O2 (about 1L)
customthe mixture was reacted for 20 hours at 110° C.

출처 및 근거

ORD 기록: ord-aec03bee9da5464ca1e458d8bae2b610
출처 데이터셋: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06468487B1

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