Hydrochloric Acid → 2-Bromo-4-chlorobenzene-1-thiol

HRID 992486노트

반응식

HRID 992486 반응식
[Br:1][C:2]12[S:10][CH:3]1[CH:4]=[CH:5][C:6]1([Cl:9])S[CH:7]12.[BH4-].[Na+].CO.Cl>C1COCC1>[Br:1][C:2]1[CH:7]=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[SH:10]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 4311764Sodium borohydrideHCID 86586184HCID 86586184, 화합물

생성물 1

HCID 218168372-Bromo-4-chlorobenzene-1-thiol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
23 °C

실험 절차

A solution of 2-bromo-4-chlorobenzene disulfide (3.8 g, 8.5 mmol) in THF (30 mL) was treated with NaBH4 (0.83 g, 22.0 mmol). The mixture was refluxed for a while and treated with MeOH (2 mL); heating was resumed for 0.5 hours. Mixture was cooled to 23° C., acidified with HCl (3N) and extracted with Et2O. The Et2O extracts were dried over MgSO4, filtered, and the filtrate was concentrated in vacuo to afford the title compound which was used without further purification.

후처리

  1. temperatureThe mixture was refluxed for a while
  2. temperatureheating
  3. extractionextracted with Et2O
  4. dry with materialThe Et2O extracts were dried over MgSO4
  5. filtrationfiltered
  6. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-03e0bdca654d4eacb7e9d8b325fa90b4
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06469042B1

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