Hydrochloric Acid → MLS002695130

HRID 993059노트

반응식

HRID 993059 반응식
[CH:1](=[C:8]1[C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10][C:9]1=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].O.Cl>CO>[CH2:1]([CH:8]1[C:9](=[O:16])[NH:10][C:11](=[O:15])[NH:12][C:13]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2411295-Benzylidenebarbituric acidHCID 4311764Sodium borohydride

생성물 1

HCID 260790MLS002695130

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of 5-benzylidenebarbituric Acid (4 g) in 200 ml of methanol are added portionwise 1.4 g of sodium borohydride. After 10 minutes from the end of the addition, 100 ml of water are added and the mixture is acidified with 1 N hydrochloric acid to pH=2. The solvent is evaporated off and the aqueous phase is extracted with ethyl acetate. The pooled extracts are dried over sodium sulfate and concentrated to dryness. 3.6 g of the product crystallize, m.p. 207-209° C.

후처리

  1. additionare added
  2. customThe solvent is evaporated off
  3. extractionthe aqueous phase is extracted with ethyl acetate
  4. dry with materialThe pooled extracts are dried over sodium sulfate
  5. concentrationconcentrated to dryness
  6. custom3.6 g of the product crystallize

출처 및 근거

ORD 기록
ord-8fe768fe0fed4a3999ca21754de35712
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472396B1

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