反应详情

To a suspension of 210 mg of N-(12-hydroxydodecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide in 10 ml of methylene chloride were added 0.03 ml of pyridine, 115 mg of tosyl chloride and a catalytic amount of 4-dimethylaminopyridine and the mixture was stirred at room temperature for one hour. The reaction solution was washed with water and a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the residue thus obtained was chromatographed over a silica gel column to afford 219 mg of the title compound.

1. washThe reaction solution was washed with water
2. dry with materiala saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customthe residue thus obtained
5. customwas chromatographed over a silica gel column