Hydrochloric Acid → 12-Aminododecyl methanesulfonate hydrochloride

HRID 1003312Notes

Reaction equation

HRID 1003312 reaction equation
[S:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18]C(=O)OC(C)(C)C)([CH3:4])(=[O:3])=[O:2].[ClH:26].CCCCCC>C(OCC)(=O)C>[ClH:26].[CH3:4][S:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])(=[O:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 18796422tert-butyl N-(12-mesyloxydodecyl)carbamate

Product 1

HCID 1879641312-Aminododecyl methanesulfonate hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 8.06 g of tert-butyl N-(12-mesyloxydodecyl)carbamate in 60 ml of ethyl acetate was added 10 ml of hydrochloric acid under ice-cooling and the mixture was stirred at room temperature for one hour. The reaction solution was cooled with ice, hexane was added, the crystal thus precipitated out was recovered by filtration and dried under reduced pressure to afford the title compound.

Workup

  1. temperaturecooling
  2. additionwas added
  3. customthe crystal thus precipitated out
  4. filtrationwas recovered by filtration
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-f490ffdc90cf4417967bb689337bc940
Source dataset
uspto-grants-2000_04
Patent number
US06046201

Reaction notes

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