反应详情

To a solution of 0.33 g of tert-butyl N-(12-iodododecyl)carbamate in 25 ml of ethyl acetate was added 2.6 ml of hydrochloric acid and the mixture was stirred for 0.5 hour. The reaction solution was distilled off under reduced pressure. The residue was dissolved in chloroform, washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Crystallization from ethyl acetate and hexane afforded 0.17 g of the title compound.

1. distillationThe reaction solution was distilled off under reduced pressure
2. dissolutionThe residue was dissolved in chloroform
3. washwashed with water
4. dry with materialdried over anhydrous sodium sulfate
5. distillationThe solvent was distilled off under reduced pressure
6. customCrystallization from ethyl acetate and hexane