反应详情

3-Acetyl-4-hydroxybenzoic acid (3.60 g, 20 mmol) and methyl iodide (5.68 g, 40 mmol) were dissolved in 60 ml of DMF, followed by the addition of 11.06 g (80 mmol) of potassium carbonate. The resulting mixture was stirred at room temperature for 2 hours. The DMF was distilled off under reduced pressure, followed by the addition of water. The resulting mixture was extracted with chloroform. The organic layer was dried over MgSO4, the solvent was distilled off under reduced pressure, and the residue was recrystallized from acetone-hexane, whereby 1.42 g of the title compound were obtained as brown powder (yield: 34%).

1. distillationThe DMF was distilled off under reduced pressure
2. additionfollowed by the addition of water
3. extractionThe resulting mixture was extracted with chloroform
4. dry with materialThe organic layer was dried over MgSO4
5. distillationthe solvent was distilled off under reduced pressure
6. customthe residue was recrystallized from acetone-hexane