4-Pentynoic acid → HCID 18362936, compound

HRID 1003369Notes

Reaction equation

HRID 1003369 reaction equation
I[C:2]1[N:3]([CH2:18][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=[CH:21][CH:20]=2)[CH:4]=[C:5]2[C:10]=1[C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[N:6]2[CH2:14][CH:15]([CH3:17])[CH3:16].[C:29]([OH:35])(=[O:34])[CH2:30][CH2:31][C:32]#[CH:33].C[Si](N([Si](C)(C)C)C(=O)C(F)(F)F)(C)C>>[CH3:12][N:8]1[C:9](=[O:11])[C:10]2=[C:2]([C:33]#[C:32][CH2:31][CH2:30][C:29]([OH:35])=[O:34])[N:3]([CH2:18][C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][CH:20]=3)[CH:4]=[C:5]2[N:6]([CH2:14][CH:15]([CH3:16])[CH3:17])[C:7]1=[O:13]

Participants

4

Reactant 3

HCID 224644-Pentynoic acidHCID 65279N,N-Bis(trimethylsilyl)trifluoroacetamideHCID 18362930HCID 18362930, compound

Product 1

HCID 18362936HCID 18362936, compound

Procedure

The sub-title compound was prepared from 5-iodo-3-methyl-1-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, and 4-pentynoic acid in the presence of bistrimethylsilyltrifluoroacetamide in a manner analogous to the method of Example 13 above.

Sources & evidence

ORD record
ord-516c21bb66974957b2de83f4a34b3515
Source dataset
uspto-grants-2000_04
Patent number
US06046204

Reaction notes

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