Acetonitrile → HCID 9838264, compound

HRID 1003420Notes

Reaction equation

HRID 1003420 reaction equation
C(O[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O)CC.[C:14]([O:17][CH2:18][CH3:19])(=O)C.C[O-].[Na+].[C:23]([CH2:25][C:26]([NH2:28])=[O:27])#[N:24].[C:29](#N)[CH3:30]>>[C:23]([C:25]1[C:26](=[O:27])[NH:28][C:10]([C:9]2[CH:8]=[CH:6][CH:5]=[CH:19][C:18]=2[O:17][CH2:14][CH2:29][CH3:30])=[CH:11][C:12]=1[CH3:13])#[N:24]

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 7898CyanoacetamideHCID 8857Ethyl AcetateHCID 10942334Sodium MethoxideHCID 12715559HCID 12715559, compound

Product 1

HCID 9838264HCID 9838264, compound

Procedure

In a similar manner to that of Example 26, 2-propoxyacetophenone (8.9 g) was allowed to react with ethyl acetate in the presence of sodium methoxide, and the intermediate was cyclised with cyanoacetamide to give the title compound, 0.2 g, m.p. 180°-180.5° C. (from acetonitrile).

Sources & evidence

ORD record
ord-eaa31df2ea9c462ea37623e5b5ae68ee
Source dataset
uspto-grants-2000_04
Patent number
US06046216

Reaction notes

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