反应详情

3.00 g (0.015 mol) of 4,6-dichloroquinazoline and 3.80 g (0.0170 mol) of 4-chloro-3-nitrobenzylamine hydrochloride were dissolved in a mixture comprising 100 ml of isopropyl alcohol and 15 ml of triethylamine. The obtained solution was heated under reflux for 24 hours and distilled under a reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (chloroform/ethyl acetate) and recrystallized from chloroform/n-hexane to give 4.85 g of the title compounds as a pale-yellow crystal.

1. temperatureThe obtained solution was heated
2. temperatureunder reflux for 24 hours
3. distillationdistilled under a reduced pressure
4. customto remove the solvent
5. customThe residue was purified by silica gel column chromatography (chloroform/ethyl acetate)
6. customrecrystallized from chloroform/n-hexane