反应详情

30 ml of 2-propanol, 1.07 g of triethylamine and 1.01 g of α-ethoxycarbonyl-3,4-methylenedioxybenzylamine were added to 704 mg of 4,6-dichloroquinazoline. The obtained mixture was refluxed for 4 hours, followed by the addition of water. The obtained mixture was extracted with chloroform thrice. The chloroform layers were combined, dried over magnesium sulfate and distilled under a reduced pressure to remove the solvent. The residue was recrystallized (from ethanol/ethyl acetate/hexane) to give 1.167 g of the title compound.

1. temperatureThe obtained mixture was refluxed for 4 hours
2. extractionThe obtained mixture was extracted with chloroform thrice
3. dry with materialdried over magnesium sulfate
4. distillationdistilled under a reduced pressure
5. customto remove the solvent
6. customThe residue was recrystallized (from ethanol/ethyl acetate/hexane)