反应详情

3.9 g of 3-chloro-4-methoxybenzylamine, 3.97 g of triethylamine and 200 ml of 2-propanol were added to 4 g of 2,4-dichloro-6-cyanoquinazoline. The obtained mixture was refluxed for 30 minutes, cooled to room temperature and filtered to recover a crystalline precipitate. The precipitate was washed with water and chloroform successively to give 5.563 g of the title compound.

1. temperatureThe obtained mixture was refluxed for 30 minutes
2. filtrationfiltered
3. customto recover a crystalline precipitate
4. washThe precipitate was washed with water and chloroform successively