反应详情

A solution of 4-phthalimidobutyraldehyde diethyl acetal (125 g, 0.43 mol) in a 1:1 mixture of tetrahydrofuran and 2N hydrochloric acid (800 ml) was heated at reflux for 0.75 h. The mixture was cooled, concentrated to 400 ml and extracted into dichloromethane (3×200 ml). Combined organics were dried (Na2SO4) and evaporated in vacuo to afford the title compound as a brown oil that solidified on standing (95 g, 100%).

1. temperaturewas heated
2. temperatureat reflux for 0.75 h
3. temperatureThe mixture was cooled
4. concentrationconcentrated to 400 ml
5. extractionextracted into dichloromethane (3×200 ml)
6. dry with materialCombined organics were dried (Na2SO4)
7. customevaporated in vacuo