Hydrogen Peroxide → HCID 22996259, compound

HRID 1003796Notes

Reaction equation

HRID 1003796 reaction equation
Cl.[NH2:2][C:3]([CH3:22])([CH3:21])[CH2:4][CH2:5][C:6]1[CH:20]=[CH:19][C:9]([O:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)=[CH:8][CH:7]=1.C(=O)([O-])[O-:24].[K+].[K+].OO.O>CS(C)=O>[NH2:2][C:3]([CH3:22])([CH3:21])[CH2:4][CH2:5][C:6]1[CH:20]=[CH:19][C:9]([O:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]([NH2:16])=[O:24])=[CH:13][CH:12]=2)=[CH:8][CH:7]=1

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 11430Potassium CarbonateHCID 22996260HCID 22996260, compound

Product 1

HCID 22996259HCID 22996259, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

4-(4-(3-Amino-3-methylbutyl)phenoxy)benzonitrile hydrochloride (1.04 g, 32.8 mmol) was dissolved in DMSO (30 ml) and treated with potassium carbonate (0.68 g, 49.2 mmol, 1.5 eq.) with stirring. After 10 minutes, hydrogen peroxide (7 ml, 30% aqueous solution) was added dropwise slowly. The mixture was allowed to stir for 16 hours and then added to 300 ml of water, causing a white precipitate. The material was filtered and dried to give a white solid (908 mg, 93%). NMR, MS

Workup

  1. stirringto stir for 16 hours
  2. filtrationThe material was filtered
  3. customdried

Sources & evidence

ORD record
ord-b68fa441971e4b3ea08b99e56da87a37
Source dataset
uspto-grants-2000_04
Patent number
US06046227

Reaction notes

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