Barium Sulfate → 1-(4-(Benzyloxy)phenyl)-4-methylpentan-3-one

HRID 1003809Notes

Reaction equation

HRID 1003809 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O-]S([O-])(=O)=O.[Ba+2]>[Pd].C1COCC1>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][C:17](=[O:21])[CH:18]([CH3:19])[CH3:20])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 24414Barium SulfateHCID 4714761-(4-Benzyloxyphenyl)-4-methyl-pent-1-en-3-one

Product 1

HCID 187986371-(4-(Benzyloxy)phenyl)-4-methylpentan-3-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Hydrogenation of 50 g (190 mmol) of 1-(4-benzyloxy-phenyl)-4-methyl-pent-1-en-3-one prepared in Example B was effected as described in General Method 3 using 1.08 g 5% Pd over BaSO4 and 1000 mL of THF under hydrogen atmosphere.

Sources & evidence

ORD record
ord-d58ced33f6a04cf7b72a4cc93c1ad377
Source dataset
uspto-grants-2000_04
Patent number
US06046355

Reaction notes

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