HRID1003920

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23831

(4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

C8H18N2O4S

结构：CC(=O)N[C@@H]1[C@@H](O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H](OS(=O)(=O)O)O[C@H]1O

HCID24766

(2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-Acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid

C13H21NO15S

结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@@H]1c1cccc([N+](=O)[O-])c1.Cl

HCID6918096

Dexniguldipine hydrochloride

C36H40ClN3O6

结构：CCC(CC(CC(CC(C)C(=O)[O-])C(=O)[O-])C(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+].[Na+]

HCID73357449

未命名化合物

2 次

PRODUCTS

生成物

结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@@H]1c1cccc([N+](=O)[O-])c1

HCID6918097

(+)-Niguldipine

C36H39N3O6

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Various other hydrophilic polymers were investigated for there use in producing dispersions of Dexniguldipine Hydrochloride. 0.1 mL of a solution containing 2 mg/mL Dexniguldipine Hydrochloride in 50% aqueous DMSO was added to 1 mL of HEPES-NS containing 10 mg of one of the following polymers: Chondroitin Sulfate A, Dextran Sulfate, polyacrylic acid sodium salt (MW 150,000), polyacrylic acid sodium salt (MW 2000) or Dextran (MW 70,000). A control group containing no polymer was also investigated. Each mixture was vortexed for 1 minute and allowed to sit for 24 hours at room temperature. After this time period the mixtures were votexed again for 15 minutes after which the quality and stability of the dispersions were visually evaluated. Stable dispersions were produced only in the mixtures that contained polyanions.

WORKUP

后处理

additionA control group containing no polymer
waitto sit for 24 hours at room temperature
waitAfter this time period the mixtures were votexed again for 15 minutes
customStable dispersions were produced only in the mixtures that

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-16999cd43a52480d83668d5f1b56698a
来源数据集: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06048550
来源说明: uspto-grants-2000_04

反应 SMILES

[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][CH2:12][CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][C:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)=[O:10])[C@H:4]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([N+:39]([O-:41])=[O:40])[CH:34]=2)[C:3]=1[C:42]([O:44][CH3:45])=[O:43].Cl.C1N(CCO)CCN(CCS(O)(=O)=O)C1.CC(N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O)=O.CCC(C([O-])=O)CC(C([O-])=O)CC(C([O-])=O)CC(C([O-])=O)C.[Na+].[Na+].[Na+].[Na+]>CS(C)=O>[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][CH2:12][CH2:13][CH2:14][N:15]2[CH2:16][CH2:17][C:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:19][CH2:20]2)=[O:10])[C@H:4]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([N+:39]([O-:41])=[O:40])[CH:34]=2)[C:3]=1[C:42]([O:44][CH3:45])=[O:43]