Acetic Acid → 1-iodo-2,3-dimethoxybenzene

HRID 1003933Notes

Reaction equation

HRID 1003933 reaction equation
CO[C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([O:10][CH3:11])[CH:9]=1)N.N([O-])=O.[Na+].Cl.[I-:17].[K+].[C:19]([OH:22])(=O)C>>[CH3:11][O:10][C:8]1[C:7]([O:22][CH3:19])=[C:5]([I:17])[CH:4]=[CH:3][CH:9]=1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 4875Potassium IodideHCID 663013,5-DimethoxyanilineHCID 23668193Sodium Nitrite

Product 1

HCID 27593631-iodo-2,3-dimethoxybenzene

Procedure

converting 3,5-dimethoxyaniline into a diazonium salt thereof with using sodium nitrite in acetic acid in the presence of a hydrochloric acid, and reacting the product with potassium iodide to give dimethoxyiodobenzene;

Sources & evidence

ORD record
ord-e817abf4cc5c4384aa110159b18ed604
Source dataset
uspto-grants-2000_04
Patent number
US06048842

Reaction notes

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