反应详情

17.6 g (0.11 mol) of 2-chloro-4-fluoroanisole was dissolved in a dichloromethane solution of 1N titanium tetrachloride, and 88.3 g (1.10 mol) of methoxymethyl chloride was dropwise added thereto at room temperature, followed by stirring at room temperature for 5 hours. after completion of the reaction, the reaction solution was poured into water, followed by stirring at room temperature for 2 hours, and then the aqueous phase was removed. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off. Then, the obtained residue was purified by silica gel column chromatography to obtain 15.5 g (yield: 68%) of the desired product.

1. additionwas dropwise added
2. customat room temperature
3. customafter completion of the reaction
4. stirringby stirring at room temperature for 2 hours
5. customthe aqueous phase was removed
6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
7. distillationthe solvent was distilled off
8. customThen, the obtained residue was purified by silica gel column chromatography