Hydrochloric Acid → HCID 9948611, compound

HRID 1004068Notes

Reaction equation

HRID 1004068 reaction equation
CC(C)([O-])C.[K+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:17]3[CH2:18][CH2:19][N:20]4[C:25]([C:16]=3[NH:15][C:12]2=[CH:13][CH:14]=1)=[C:24]([CH2:26][CH3:27])[CH2:23][CH2:22][C:21]4=[S:28].O.Cl>CN(C=O)C>[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:17]3[CH:18]=[CH:19][N:20]4[C:25]([C:16]=3[NH:15][C:12]2=[CH:13][CH:14]=1)=[C:24]([CH2:26][CH3:27])[CH2:23][CH2:22][C:21]4=[S:28]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 9796811HCID 9796811, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 9948611HCID 9948611, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Potassium tert-butoxide (665 mg, 5.9 mmol) is added to a solution of 9-methoxy-1-ethyl-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizine-4-thione (500 mg, 1.6 mmol) in DMF (42 ml). After placing the reaction assembly under vacuum, the mixture is stirred under normal oxygen pressure overnight. Water (15 ml) and concentrated hydrochloric acid (3 ml) are then successively added. The solution is stored in a refrigerator for 4 hours. After filtration, 9-methoxy-1-ethyl-2,3,4,12-tetrahydroindolo[2,3-a]quinolizine-4-thione is obtained (150 mg, Y=30%).

Workup

  1. customthe reaction assembly under vacuum
  2. waitThe solution is stored in a refrigerator for 4 hours
  3. filtrationAfter filtration

Sources & evidence

ORD record
ord-224b86aef95e4382a3b42db3a9a154dd
Source dataset
uspto-grants-2000_04
Patent number
US06048868

Reaction notes

Loading…