反应详情

2-(4 nitro-2-chlorophenyl )acetic acid methyl ester was reduced with tin chloride in methanol at reflux for 2 h. The solution was poured over ice and neutralized with saturated sodium bicarbonate. The mixture was extracted with methylene chloride, dried (MgSO4), and concentrated. The oil was purified by silica gel chromatography eluted with hexane/ethyl acetate(9:1 to 8:2) to yield the title compound (0.81 g).

1. temperatureat reflux for 2 h
2. extractionThe mixture was extracted with methylene chloride
3. dry with materialdried (MgSO4)
4. concentrationconcentrated
5. customThe oil was purified by silica gel chromatography
6. washeluted with hexane/ethyl acetate(9:1 to 8:2)