反应详情

1.1 equivalents of sodium hydride and then 0.033 mol of the product obtained in Step D are added at room temperature and under an inert atmosphere to a solution of 0.036 mol of 4-methoxyphenol in 250 ml of dimethylformamide. After 12 hours' reaction, the reaction mixture is concentrated under reduced pressure. The residue is then diluted in ethyl acetate, washed with water and then with an aqueous NaCl solution, dried over calcium sulphate, filtered and concentrated under reduced pressure. Chromatography over silica gel (dichloromethane/ethyl acetate: 98/2) enables 8.6 g of the expected product to be isolated.

1. customAfter 12 hours' reaction
2. concentrationthe reaction mixture is concentrated under reduced pressure
3. additionThe residue is then diluted in ethyl acetate
4. washwashed with water
5. dry with materialwith an aqueous NaCl solution, dried over calcium sulphate
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. customto be isolated