反应详情

温度

120 °C

A mixture of 1.27 g of the compound (9) synthesized in Example 2 and 0.8 g of 2,3,4-trimethoxybenzaldehyde was stirred at 120° C., then, 0.18 ml of formic acid was added dropwise. This was stirred for one hour at the same temperature, then ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate were added and the results were shaken. The organic layer was dried, filtered, then concentrated under reduced pressure to obtain a residue which was then purified by silica gel column chromatography (hexane:ethyl acetate=3:2) to obtain the above-referenced compound (29) in an amount of 1.46 g (yield 73%).

1. stirringThis was stirred for one hour at the same temperature
2. stirringthe results were shaken
3. customThe organic layer was dried
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure
6. customto obtain a residue which
7. customwas then purified by silica gel column chromatography (hexane:ethyl acetate=3:2)