Potassium Iodide → 4-(1,3-Benzodioxol-5-ylmethoxy)-2-hydroxybenzaldehyde

HRID 1004307Notes

Reaction equation

HRID 1004307 reaction equation
[OH:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH2:11]1[O:21][C:20]2[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][C:13]=2[O:12]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(C(C)=O)C>[O:21]1[C:20]2[CH:19]=[CH:18][C:15]([CH2:16][O:10][C:8]3[CH:7]=[CH:6][C:3]([CH:4]=[O:5])=[C:2]([OH:1])[CH:9]=3)=[CH:14][C:13]=2[O:12][CH2:11]1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 72132,4-DihydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 887131,3-Benzodioxole, 5-(chloromethyl)-

Product 1

HCID 106597624-(1,3-Benzodioxol-5-ylmethoxy)-2-hydroxybenzaldehydeYield 31.4%

Reagents, catalysts & solvents 2

HCID 74236Tetrabutylammonium BromideCatalystHCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 2,4-dihydroxybenzaldehyde (22.94 g), 3,4-methylenedioxybenzyl chloride (34 g), potassium carbonate (34.43 g), potassium iodide (41.33 g) and tetra-n-butylammonium bromide (6 g) in methyl ethyl ketone was heated at reflux for 3 hours. The reaction mixture was filtered and evaporated. The residue was partitioned between ethyl acetate (400 ml) and water (400 ml) and the aqueous phase extracted twice with ethyl acetate (200 ml). The combined organic phases were dried over magnesium sulphate and evaporated. The residual beige coloured solid was purified by flash chromatography on silica eluting initially with a mixture of pentane and ethyl acetate (95:5, v/v) then with a mixture of pentane and ethyl acetate (9:1, v/v) and finally with a mixture of pentane and ethyl acetate (85:15, v/v). Fractions homogenous in the required product were combined and evaporated to give the title compound (14.2 g) as a white solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3 hours
  3. filtrationThe reaction mixture was filtered
  4. customevaporated
  5. customThe residue was partitioned between ethyl acetate (400 ml) and water (400 ml)
  6. extractionthe aqueous phase extracted twice with ethyl acetate (200 ml)
  7. dry with materialThe combined organic phases were dried over magnesium sulphate
  8. customevaporated
  9. customwas purified by flash chromatography on silica eluting initially with a mixture of pentane and ethyl acetate (95:5
  10. additionv/v) then with a mixture of pentane and ethyl acetate (9:1
  11. additionv/v) and finally with a mixture of pentane and ethyl acetate (85:15
  12. customevaporated

Sources & evidence

ORD record
ord-dc1c0d65e37c4c9c89c498db546d68db
Source dataset
uspto-grants-2000_04
Patent number
US06048893

Reaction notes

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