HCID 70181726, compound → HCID 18794088, compound

HRID 1004513Notes

Reaction equation

HRID 1004513 reaction equation
I.C([O:4][C:5](=[O:19])[CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[NH:18])[NH2:17])=[CH:12][CH:11]=1)C>Cl.C(O)(=O)C>[C:16]([C:13]1[CH:14]=[CH:15][C:10]([O:9][CH2:8][CH2:7][CH2:6][C:5]([OH:19])=[O:4])=[CH:11][CH:12]=1)(=[NH:17])[NH2:18]

Participants

4

Reactant 1

HCID 70181726HCID 70181726, compound

Product 1

HCID 18794088HCID 18794088, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Conditions

Temperature
50 °C

Procedure

The compound (500 mg) obtained in the above (2) is dissolved in a mixture of 1N hydrochloric acid (5 ml) and acetic acid (5 ml), and the mixture is stirred at 50° C. for 8 hours. The reaction mixture is concentrated under reduced pressure, and the residue is dried to give the title compound (388 mg) as a brown solid.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customthe residue is dried

Sources & evidence

ORD record
ord-d8a5353539d145f88b018a2eb39b7e5c
Source dataset
uspto-grants-2000_04
Patent number
US06048854

Reaction notes

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