HCID 18793167, compound → HCID 18793137, compound

HRID 1004662Notes

Reaction equation

HRID 1004662 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:17]=[CH:18][CH:19]=1)[O:12][CH2:13][CH2:14][C:15]#[N:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CC(O)C.[Ni]>[C:2]1([CH2:1][O:8][C:9]2[CH:10]=[C:11]([CH:17]=[CH:18][CH:19]=2)[O:12][CH2:13][CH2:14][CH2:15][NH2:16])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 18793167HCID 18793167, compound

Product 1

HCID 18793137HCID 18793137, compoundYield 69.5%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 3776IsopropanolSolvent

Procedure

A mixture of 3-[m-(benzyloxy)phenoxy]-propionitrile (203 g, 0.80 mol) in 2-propanol is hydrogenated over Raney nickel catalyst (50 g). The catalyst is filtered, and the filtrate is evaporated. Distillation of the residue under high vacuum gives 143 g (69%) of product, bp 190° C. (0.15 mm).

Workup

  1. filtrationThe catalyst is filtered
  2. customthe filtrate is evaporated
  3. distillationDistillation of the residue under high vacuum

Sources & evidence

ORD record
ord-4d20e1b8beca4094a69940d28027c5c2
Source dataset
uspto-grants-2000_04
Patent number
US06051605

Reaction notes

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