反应详情

4.2 g of 3-methoxy-4-methylthiophene was added to a mixture of 40 mL of toluene, 8.2 g of 2-bromo-1-ethanol (Aldrich) and 500 mg of NaHSO4. The resulting mixture was heated until the produced methanol had been distilled off and the temperature rose to 110° C. The product was cooled and washed several times with water and, subsequently, extracted with diethyl ether. The organic phase was dried with magnesium sulfate and then evaporated. The product was purified by column chromatography using silica gel and hexanes as eluent. Yield=55%.

1. distillationhad been distilled off
2. customrose to 110° C
3. temperatureThe product was cooled
4. washwashed several times with water
5. extractionsubsequently, extracted with diethyl ether
6. dry with materialThe organic phase was dried with magnesium sulfate
7. customevaporated
8. customThe product was purified by column chromatography