Acetic Acid → HCID 18791026, compound

HRID 1005286Notes

Reaction equation

HRID 1005286 reaction equation
C(O)(=O)C.C(O)C.[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[C:12]([N+:16]([O-])=O)=[CH:11][C:10]=1[C:19]1[C:23]([C:24]([F:27])([F:26])[F:25])=[C:22]([C:28]([F:31])([F:30])[F:29])[N:21]([CH3:32])[N:20]=1>[Fe].C(OCC)(=O)C>[NH2:16][C:12]1[C:13]([Cl:15])=[CH:14][C:9]([Cl:8])=[C:10]([C:19]2[C:23]([C:24]([F:25])([F:26])[F:27])=[C:22]([C:28]([F:31])([F:30])[F:29])[N:21]([CH3:32])[N:20]=2)[CH:11]=1

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 702EthanolHCID 18791015HCID 18791015, compound

Product 1

HCID 18791026HCID 18791026, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 8857Ethyl AcetateSolvent

Procedure

8 g (0.14 mol) of iron powder, 53 ml of glacial acetic acid and 24 ml of ethanol were heated to 70° C. and the mixture was treated with 11.7 g (29 mmol) of 3-(2,4-dichloro-5-nitrophenyl)-1-methyl-4,5-di(trifluoromethyl)-1H-pyrazole. After the mixture had been stirred for 2 hours at reflux temperature, it was treated with 200 ml of ethyl acetate. It was then filtered through kieselguhr. The filtrate was concentrated. Yield: quantitative.

Workup

  1. temperatureat reflux temperature, it
  2. filtrationIt was then filtered through kieselguhr
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-a52fbd77163f42bfb0399023c31848c1
Source dataset
uspto-grants-2000_04
Patent number
US06054412

Reaction notes

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