Oxalyl chloride → HCID 18791165, compound

HRID 1005350Notes

Reaction equation

HRID 1005350 reaction equation
[C:1]([CH2:3][CH:4]1[CH2:7][CH:6]([C:8]([OH:10])=O)[CH2:5]1)#[N:2].C(Cl)(=O)C([Cl:14])=O>ClCCl.CN(C)C=O>[C:1]([CH2:3][CH:4]1[CH2:7][CH:6]([C:8]([Cl:14])=[O:10])[CH2:5]1)#[N:2]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 18791123HCID 18791123, compound

Product 1

HCID 18791165HCID 18791165, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 3-cyanomethylcyclobutane carboxylic acid (4.0 g, 28.8 mmol) in dichloromethane (50 ml) was added two drops of dimethylformamide followed by oxalyl chloride (12 ml). The mixture was stirred overnight at room temperature followed by removal of the solvent and excess reagent in vacuo. The resulting oil was dissolved in dry dichloromethane and the solvent evaporated to give the title compound as an oil.

Workup

  1. customfollowed by removal of the solvent and excess reagent in vacuo
  2. dissolutionThe resulting oil was dissolved in dry dichloromethane
  3. customthe solvent evaporated

Sources & evidence

ORD record
ord-0fdbc777a6e74454bb01d645067e2f4a
Source dataset
uspto-grants-2000_04
Patent number
US06054448

Reaction notes

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