Pentanoyl chloride, 4-methyl- → 2-(4-Methyl-1-oxopentyl)furan

HRID 1005478Notes

Reaction equation

HRID 1005478 reaction equation
C([Sn](CCCC)(CCCC)[C:6]1[O:7][CH:8]=[CH:9][CH:10]=1)CCC.[CH3:19][CH:20]([CH3:26])[CH2:21][CH2:22][C:23](Cl)=[O:24]>C1COCC1>[CH3:19][CH:20]([CH3:26])[CH2:21][CH2:22][C:23]([C:6]1[O:7][CH:8]=[CH:9][CH:10]=1)=[O:24]

Participants

4

Reactant 2

HCID 170008Pentanoyl chloride, 4-methyl-HCID 43936882-(Tributylstannyl)furan

Product 1

HCID 952872-(4-Methyl-1-oxopentyl)furan

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-tributylstannylfuran (1 mmol), 4-methylvaleroyl chloride (1.1 mmol), and PdCl2 (PPh3)2 (0.05 mmol) in THF was stirred at 25° C. for 24 h. Extraction and chromatography gave 2-(4-methylvaleryl)furan.

Workup

  1. extractionExtraction and chromatography

Sources & evidence

ORD record
ord-adb24a006c4146be9f91db17b35a99ab
Source dataset
uspto-grants-2000_04
Patent number
US06054587

Reaction notes

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