Hydrochloric Acid → HCID 10109509, compound

HRID 1005574Notes

Reaction equation

HRID 1005574 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([OH:10])=O.[C:11]([N:14]1[CH2:19][CH2:18][NH:17][CH:16]([CH2:20][N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[CH2:15]1)(=[O:13])[CH3:12].[ClH:26].[NH4+].[Cl-]>>[ClH:26].[C:11]([N:14]1[CH2:19][CH2:18][N:17]([C:8](=[O:10])[CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:16]([CH2:20][N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[CH2:15]1)(=[O:13])[CH3:12]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 853182-Pyridineacetic acidHCID 22707196HCID 22707196, compound

Product 1

HCID 10109509HCID 10109509, compound

Procedure

The compound was prepared by coupling of 2-pyridylacetic acid with 4-acetyl-2-(R,S)-[(1-pyrrolidinyl)methyl]piperazine; mp: (HCl salt) 127-130° C.; 1H NMR (free base, 200 MHz, CDCl3) δ1.4-1.7 (4 H, m), 2.0 (3 H, s), 2.2-3.2 (9 H, m), 3.4-4.8 (6 H, m), 6.8-7.5 (3 H, m), 8.4 (1 H, m); MS (FAB) 331 (M+H)+ ; Anal. Calcd. for C18H26N4O2.2HCl. 0.5 NH4Cl: C, 50.27; H, 7.03; N, 14.65. Found: C, 50.86; H, 6.47; N, 15.79.

Sources & evidence

ORD record
ord-d479cf1bc57d407ab2de6bf8c235950b
Source dataset
uspto-grants-2000_04
Patent number
US06054445

Reaction notes

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