反应详情

A mixture of 3-methoxy-4-nitro-N-methyl-N-[4-methyl-2-[5-(4methylpiperazin-1-ylcarbonyl)pent-1-yloxy]phenyl]benzamide (6.2 g) and iron powder (3.43 g) in a mixture of ethanol (65 ml) and ethyl acetate (6 ml) was refluxed for 2 hours. After being cooled to ambient temperature, the solution was filtered through a bed of Celite and the filtrate was evaporated in vacuo. The residue was diluted with ethyl acetate and the solution was washed with saturated sodium hydrogen carbonate and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give 4-amino-3-methoxy-N-methyl-N-[4-methyl-2-[5-(4-methylpiperazin-1-ylcarbonyl)pent-1-yloxy]phenyl]benzamide (4.7 g ).

1. temperaturewas refluxed for 2 hours
2. filtrationthe solution was filtered through a bed of Celite
3. customthe filtrate was evaporated in vacuo
4. additionThe residue was diluted with ethyl acetate
5. washthe solution was washed with saturated sodium hydrogen carbonate and brine
6. dry with materialdried over magnesium sulfate
7. customThe solvent was evaporated in vacuo