反应详情

To a solution of 4-[2-[(3-tert-butoxycarbonylaminoprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-(4-hydroxyphenyl)benzamide (50 mg) in chloroform (3.0 ml) was added a solution of 4N hydrogen chloride in ethyl acetate (1.0 ml) and the mixture was stirred at ambient temperature for 2 hours. The resulting mixture was evaporated in vacuo and the residue was solidified with diethyl ether. Diethyl ether was removed in vacuo to give 4-[2-[(3-aminoprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-(4-hydroxyphenyl)benzamide hydrochloride (40 mg).

1. customThe resulting mixture was evaporated in vacuo
2. customDiethyl ether was removed in vacuo