Hydrochloric Acid → HCID 18791644, compound

HRID 1005611Notes

Reaction equation

HRID 1005611 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:40]=[CH:39][CH:38]=[CH:37][C:14]=1[C:15]([NH:17][C:18]1[CH:34]=[CH:33][C:21]([C:22]([N:24]([CH3:32])[C:25]2[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=2)=[O:23])=[CH:20][C:19]=1[O:35][CH3:36])=[O:16])=O)(C)(C)C.[ClH:41]>C(Cl)(Cl)Cl.C(OCC)(=O)C>[ClH:41].[NH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:40]=[CH:39][CH:38]=[CH:37][C:14]=1[C:15]([NH:17][C:18]1[CH:34]=[CH:33][C:21]([C:22]([N:24]([CH3:32])[C:25]2[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=2)=[O:23])=[CH:20][C:19]=1[O:35][CH3:36])=[O:16]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54462342HCID 54462342, compound

Product 1

HCID 18791644HCID 18791644, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-[2-[(3-tert-butoxycarbonylaminoprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-(4-hydroxyphenyl)benzamide (50 mg) in chloroform (3.0 ml) was added a solution of 4N hydrogen chloride in ethyl acetate (1.0 ml) and the mixture was stirred at ambient temperature for 2 hours. The resulting mixture was evaporated in vacuo and the residue was solidified with diethyl ether. Diethyl ether was removed in vacuo to give 4-[2-[(3-aminoprop-1-yl)oxy]benzoyl]amino-3-methoxy-N-methyl-N-(4-hydroxyphenyl)benzamide hydrochloride (40 mg).

Workup

  1. customThe resulting mixture was evaporated in vacuo
  2. customDiethyl ether was removed in vacuo

Sources & evidence

ORD record
ord-ffd0bc95e2c142a6bec21ecea7e0e46a
Source dataset
uspto-grants-2000_04
Patent number
US06054457

Reaction notes

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