反应详情

In ethanol (40 ml) was dissolved 2.1 g of N-acetyl-N-(3-nitrophenethyl)amine (Preparation Example 28), and powdered iron (2.25 g), ammonium acetate (4.3 g) and water (20 ml) were added thereto, followed by heating under reflux for 1.5 hours. The solid matter was filtered off and washed with ethanol, and a part of the filtrate was evaporated. The residue was extracted with ethyl acetate, washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound (1.723 g, 96%) as a yellow oil.

1. additionwere added
2. temperatureby heating
3. temperatureunder reflux for 1.5 hours
4. filtrationThe solid matter was filtered off
5. washwashed with ethanol
6. customa part of the filtrate was evaporated
7. extractionThe residue was extracted with ethyl acetate
8. washwashed with brine
9. dry with materialdried over anhydrous magnesium sulfate
10. customthe solvent was evaporated