Hydrochloric Acid → HCID 22674054, compound

HRID 1005692Notes

Reaction equation

HRID 1005692 reaction equation
C([NH:8][CH:9]([CH3:23])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:12]=1)(OC(C)(C)C)=O.[ClH:24]>C(O)C>[ClH:24].[CH2:21]([O:20][C:18]([NH:17][C:13]1[CH:12]=[C:11]([CH2:10][CH:9]([NH2:8])[CH3:23])[CH:16]=[CH:15][CH:14]=1)=[O:19])[CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 22674117HCID 22674117, compound

Product 1

HCID 22674054HCID 22674054, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (5 ml) was dissolved 1.173 g of N-Boc-1-methyl-2-(3-ethoxycarbonylaminophenyl)ethylamine (crude), and hydrochloric acid (5 ml) was added thereto, followed by stirring at room temperature for 1.5 hours. Then, hydrochloric acid (2.5 ml) was further added thereto, followed by stirring at room temperature for 2 hours. The solvent was evaporated, to give the title compound (1.148 g, crude) as a yellow oil. The obtained compound was subjected to the subsequent reaction as intact without further purification.

Workup

  1. additionwas added
  2. stirringby stirring at room temperature for 2 hours
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-509a73bca1f54511a7e943ed86e1a297
Source dataset
uspto-grants-2004_09
Patent number
US06787534B2

Reaction notes

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