Hydrochloric Acid → HCID 22674466, compound

HRID 1005711Notes

Reaction equation

HRID 1005711 reaction equation
C(OC([NH:8][CH2:9][CH2:10][NH:11][C:12]1[N:13]=[C:14]([C:21]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)=[O:22])[C:15]2[S:20][CH:19]=[CH:18][C:16]=2[N:17]=1)=O)CCC.[ClH:28]>CO.O1CCOCC1>[ClH:28].[ClH:28].[NH2:8][CH2:9][CH2:10][NH:11][C:12]1[N:13]=[C:14]([C:21]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)=[O:22])[C:15]2[S:20][CH:19]=[CH:18][C:16]=2[N:17]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22674383HCID 22674383, compound

Product 1

HCID 22674466HCID 22674466, compoundYield 77%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 2-(2-butoxycarbonylaminoethylamino)thieno[3,2-d]pyrimidin-4-yl 2-thienylmethanone (58 mg, 0.14 mmol) in MeOH (5 mL) was treated with 4-M HCl in dioxane (0.5 mL), stirred at room temperature for 16 h and the resulting solid filtered and washed with ether to give the title compound (41 mg, 77%) as a white crystalline solid.

Workup

  1. filtrationthe resulting solid filtered
  2. washwashed with ether

Sources & evidence

ORD record
ord-6e75937168a246419193d4998cb1c85a
Source dataset
uspto-grants-2004_09
Patent number
US06787541B1

Reaction notes

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