Hydrochloric Acid → HCID 22674368, compound

HRID 1005715Notes

Reaction equation

HRID 1005715 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[C:9]2[S:21][CH:20]=[CH:19][C:10]=2[N:11]=[C:12]([C:14]([O:16]CC)=[O:15])[N:13]=1)=[O:7].[OH-].[Na+].Cl>CO.O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[C:9]2[S:21][CH:20]=[CH:19][C:10]=2[N:11]=[C:12]([C:14]([OH:16])=[O:15])[N:13]=1)=[O:7]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22674421HCID 22674421, compound

Product 1

HCID 22674368HCID 22674368, compoundYield 50%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of ethyl 4-(2-thienylcarbonyl)thieno[3,2-d]pyrimidine-2-carboxylate (80 mg, 0.25 mmol) in MeOH (3 mL) was treated with 2M-NaOH (1 mL), stirred at room temperature for 20 min, acidified with 1M-HCl, diluted with water and filtered to give the title compound (36 mg, 50%) as a pale yellow solid.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-e59f9990e00240438bac97894d704ee6
Source dataset
uspto-grants-2004_09
Patent number
US06787541B1

Reaction notes

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