Water → HCID 22674396, compound

HRID 1005724Notes

Reaction equation

HRID 1005724 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5]1[N:6]=[C:7]([C:14]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)=[O:15])[C:8]2[S:13][CH:12]=[CH:11][C:9]=2[N:10]=1.[C:21]1([N:27]=[C:28]=[S:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.O>CN(C=O)C>[C:21]1([NH:27][C:28]([NH:1][CH2:2][CH2:3][NH:4][C:5]2[N:6]=[C:7]([C:14]([C:16]3[S:17][CH:18]=[CH:19][CH:20]=3)=[O:15])[C:8]3[S:13][CH:12]=[CH:11][C:9]=3[N:10]=2)=[S:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7673Phenyl IsothiocyanateHCID 22674375[2-[(2-Aminoethyl)amino]thieno[3,2-d]pyrimidin-4-yl]-2-thienylmethanone

Product 1

HCID 22674396HCID 22674396, compoundYield 62.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2-(2-aminoethylamino)thieno[3,2-d]pyrimidin-4-yl 2-thienylmethanone (50 mg, 0.16 mmol) in anhydrous DMF (1 mL) was treated with phenyl isothiocyanate (33 mg, 0.25 mmol), shaken at room temperature for 2 h, poured into water (20 mL) and the resulting yellow precipitate was filtered and dried in vacuo to give the title compound (44 mg, 61%) as a yellow solid.

Workup

  1. filtrationthe resulting yellow precipitate was filtered
  2. customdried in vacuo

Sources & evidence

ORD record
ord-794673df55374f9785f4df1dd51ea6c2
Source dataset
uspto-grants-2004_09
Patent number
US06787541B1

Reaction notes

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