反应详情

The resulting propionic acid derivative (80 mg, 0.16 mmol) was dissolved in a mixture of ethanol (2 mL) and water (1 mL). To the solution was then added lithium hydroxide monohydrate (10 mg). The mixture was stirred for 20 hours at room temperature, cooled with ice, neutralized by addition of diluted hydrochloric acid, and subjected to extraction using ethyl acetate. The organic layer was collected, washed with water and brine, dried over anhydrous sodium sulfate, and filtered. The ethyl acetate was removed under reduced pressure, to give 55 mg of the desired compound as pale yellow oil residue (yield 73%).

1. temperaturecooled with ice
2. extractionsubjected to extraction
3. customThe organic layer was collected
4. washwashed with water and brine
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltered
7. customThe ethyl acetate was removed under reduced pressure