反应详情

N-Tert-butoxycarbonyl-D-valine (70 g, 0.32 mol) and cesium carbonate (200.2 g, 0.615 mol) were stirred in dry dimethylformamide (550 mL). Benzyl bromide (40.32 mL, 0.336 mol) was added and the reaction mixture was stirred overnight. The material was concentrated on the roto-evaporator and the residue was dissolved in methylene chloride (200 mL) and the methylene chloride layer was washed with water and brine, dried over magnesium sulfate and concentrated to give N-tert-butoxycarbonyl-D-valine benzyl ester (97 g) as a viscous oil.

1. concentrationThe material was concentrated on the roto-evaporator
2. dissolutionthe residue was dissolved in methylene chloride (200 mL)
3. washthe methylene chloride layer was washed with water and brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated