Hydrochloric Acid → HCID 69818612, compound

HRID 1006333Notes

Reaction equation

HRID 1006333 reaction equation
[CH:1]([CH:14]1[NH:23][CH:22]2[CH:17]([CH2:18][CH2:19][CH2:20][CH2:21]2)[N:16](C(OC(C)(C)C)=O)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:31]>C(OCC)(=O)C>[ClH:31].[ClH:31].[CH:1]([CH:14]1[CH2:15][NH:16][CH:17]2[CH:22]([CH2:21][CH2:20][CH2:19][CH2:18]2)[NH:23]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86589636HCID 86589636, compound

Product 1

HCID 69818612HCID 69818612, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-Butyl (3RS,4aSR,8aSR)-3-benzhydryloctahydroquinoxaline-1-carboxylate (42 mg) was dissolved in 4N ethyl acetate solution of hydrogen chloride (4 ml) and the mixture was stirred at ambient temperature for 3 hours. The volatile materials were removed under reduced pressure to give (2RS,4aSR,8aSR)-2-benzhydryldecahydroquinoxaline dihydrochloride (28 mg).

Workup

  1. customThe volatile materials were removed under reduced pressure

Sources & evidence

ORD record
ord-4d7e0080838840d891e532729ffcb668
Source dataset
uspto-grants-2004_09
Patent number
US06787543B2

Reaction notes

Loading…