反应详情

A solution of 4N hydrogen chloride in ethyl acetate (100 ml) was added to 1-tert-butoxycarbonyl-4-(4-fluorobenzyl)piperidine (39.9 g) and the solution was stirred for an hour at room temperature. The reaction mixture was concentrated under reduced pressure, then diethyl ether was added thereto. The resulting precipitate was collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the title compound (30.1 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additiondiethyl ether was added
3. filtrationThe resulting precipitate was collected by filtration
4. washwashed with diethyl ether
5. customdried under reduced pressure