Trifluoroacetic acid → HCID 22380625, compound

HRID 1006436Notes

Reaction equation

HRID 1006436 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[N:16]=[CH:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[N:14]1([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]=[CH:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11174123HCID 11174123, compound

Product 1

HCID 22380625HCID 22380625, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(tert-Butoxycarbonyl)-4-(1H-benzimidazol-1-yl)piperidine (192 mg) was dissolved in dichloromethane (1.9 ml), added with trifluoroacetic acid (1.9 ml) and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and added with diisopropyl ether, and then the produced crystals were collected by filtration to obtain 200 mg of the title compound. Yield: 100%.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionadded with diisopropyl ether
  3. filtrationthe produced crystals were collected by filtration

Sources & evidence

ORD record
ord-0b7d13f31b77497f8bf80a21ea10e261
Source dataset
uspto-grants-2004_09
Patent number
US06790854B2

Reaction notes

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