Potassium Carbonate → HCID 85876215, compound

HRID 1006465Notes

Reaction equation

HRID 1006465 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6]([Cl:11])[C:3]=1[CH:4]=[O:5].Br[CH2:13][C:14]([O:16][CH3:17])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:9]=[C:8]([CH:7]=[C:6]([Cl:11])[C:3]=1[CH:4]=[O:5])[O:10][CH2:13][C:14]([O:16][CH3:17])=[O:15]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 5283822,6-Dichloro-4-hydroxybenzaldehyde

Product 1

HCID 85876215HCID 85876215, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 382 mg (2.0 mmol) A1, 337 mg (2.2 mmol) methyl bromoacetate and 387 mg (2.8 mmol) potassium carbonate in 6 ml dry acetone were stirred for 2 h at 60° C. After filtration and removal of the solvent the residue was purified by column chromatography on SiGel (hexane/ethyl acetate 4:1). Yield: 508 mg (97%) A4, colorless solid.

Workup

  1. filtrationAfter filtration and removal of the solvent the residue
  2. customwas purified by column chromatography on SiGel (hexane/ethyl acetate 4:1)

Sources & evidence

ORD record
ord-19027a950146492f8ba3f1283de5e945
Source dataset
uspto-grants-2004_09
Patent number
US06790852B2

Reaction notes

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