N-methyl-2-pyrrolidone → HCID 9885291, compound

HRID 1006490Notes

Reaction equation

HRID 1006490 reaction equation
Cl[C:2]1[C:3]2[S:18][C:17]([NH2:19])=[N:16][C:4]=2[N:5]=[C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]=1.[NH2:20][C@H:21]([CH2:24][CH3:25])[CH2:22][OH:23].CN1CCCC1=O.C(N(CC)C(C)C)(C)C>O>[NH2:19][C:17]1[S:18][C:3]2[C:2]([NH:20][C@H:21]([CH2:24][CH3:25])[CH2:22][OH:23])=[N:7][C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:5][C:4]=2[N:16]=1

Participants

6

Reactant 4

HCID 13387N-methyl-2-pyrrolidoneHCID 81531DiisopropylethylamineHCID 27238562-Amino-1-butanol, (-)-HCID 112782745-(Benzylthio)-7-chloro[1,3]thiazolo[4,5-d]pyrimidin-2-amine

Product 1

HCID 9885291HCID 9885291, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of the product of example 1 step c) (2.5 g) and (R)-(−)-2-amino-1-butanol (5 g) in a solvent of N-methylpyrrolidinone (10 ml) was added N,N-diisopropylethylamine (5 ml) and the resultant mixture heated at 100° C. for 10 hours. The mixture was poured into water and the product collected by filtration to give the subtitle compound (2.5 g)

Workup

  1. filtrationthe product collected by filtration

Sources & evidence

ORD record
ord-bf0f0944e86f455ca9e25f70042e72cf
Source dataset
uspto-grants-2004_09
Patent number
US06790850B1

Reaction notes

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