HRID1006517

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1030

1,2-Propylene glycol

C3H8O2

结构：CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F

HCID39212

未命名化合物

结构：CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1

HCID114811

Florfenicol

C12H14Cl2FNO4S

PRODUCTS

生成物

结构：CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F

HCID86602307

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

The N-methyl-2-pyrrolidone, propylene glycol and approximately 90% of the PEG 300 required were charged to the compounding vessel and mixed well. The florfenicol and flunixin meglumine were added with mixing until all solids were dissolved. The volume was adjusted with the remaining PEG 300.

WORKUP

后处理

additionmixed well
additionwith mixing until all solids
dissolutionwere dissolved

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-367a363c259c4279b1582a1a91f894dd
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06790867B2
来源说明: uspto-grants-2004_09

反应 SMILES

C(O)C(O)C.[CH3:6][S:7]([C:10]1[CH:11]=[CH:12][C:13]([C@@H:16]([OH:26])[C@H:17]([NH:20][C:21]([CH:23]([Cl:25])[Cl:24])=[O:22])[CH2:18][F:19])=[CH:14][CH:15]=1)(=[O:9])=[O:8].[CH3:27][C:28]1[C:33]([NH:34][C:35]2[N:40]=[CH:39][CH:38]=[CH:37][C:36]=2[C:41]([OH:43])=[O:42])=[CH:32][CH:31]=[CH:30][C:29]=1[C:44]([F:47])([F:46])[F:45].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>CN1CCCC1=O>[CH3:6][S:7]([C:10]1[CH:11]=[CH:12][C:13]([C@@H:16]([OH:26])[C@H:17]([NH:20][C:21]([CH:23]([Cl:25])[Cl:24])=[O:22])[CH2:18][F:19])=[CH:14][CH:15]=1)(=[O:9])=[O:8].[CH3:27][C:28]1[C:33]([NH:34][C:35]2[N:40]=[CH:39][CH:38]=[CH:37][C:36]=2[C:41]([OH:43])=[O:42])=[CH:32][CH:31]=[CH:30][C:29]=1[C:44]([F:46])([F:45])[F:47]