Dimethylamine → HCID 23378634, compound

HRID 1006555Notes

Reaction equation

HRID 1006555 reaction equation
COC[O:4][C:5]([CH2:7][N:8]([S:33]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)(=[O:35])=[O:34])[C:9]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][C:10]=1[O:11][CH2:12][C:13]1[CH:24]=[CH:23][C:16]([C:17]([O:19][CH2:20][O:21][CH3:22])=[O:18])=[CH:15][CH:14]=1)=O.[CH3:42][NH:43][CH3:44]>C1COCC1>[CH3:42][N:43]([C:5]([CH2:7][N:8]([S:33]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)(=[O:34])=[O:35])[C:9]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][C:10]=1[O:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]([C:17]([O:19][CH2:20][O:21][CH3:22])=[O:18])=[CH:23][CH:24]=1)=[O:4])[CH3:44]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 23378635HCID 23378635, compound

Product 1

HCID 23378634HCID 23378634, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4-[2-(N-methoxymethoxycarbonylmethyl-phenylsulfonylamino)-5-trifluoromethylphenoxymethyl]benzoic acid. methoxymethyl ester (476 mg; prepared in Reference Example 35) in THF (2 ml), dimethylamine(0.8 ml) was added. The mixture was stirred for 3 days at room temperature. The solvent was distilled off. The residue was purified on silica gel column chromatography (hexane:AcOEt=2:1→1:1) to give the title compound (290 mg) having the following physical data.

Workup

  1. distillationThe solvent was distilled off
  2. customThe residue was purified on silica gel column chromatography (hexane:AcOEt=2:1→1:1)

Sources & evidence

ORD record
ord-24e2eef8130f4c0398d764f165eb5ea6
Source dataset
uspto-grants-2004_09
Patent number
US06790866B2

Reaction notes

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