反应详情

温度

25 °C

To a solution of 14.1 g (47.7 mmol, 1.00 equiv.) of t-butyl 4-(acetoxymethyl)-3-nitrobenzoate in MeOH (200 mL) was added 27.0 mL (477 mmol, 10.0 equiv.) of hydrazine hydrate (55% hydrazine). The resulting yellow solution was stirred at 25° C. for 4 hr. EtOAc (250 mL) and saturated aq. NaCl (85 mL) were added, and the organic layer collected after shaking. The organic layer was washed further with saturated aq. NaCl (2×85 mL), and then dried (MgSO4). Removal of volatiles in vacuo gave the product in 93% yield as yellow crystals.

1. customthe organic layer collected
2. stirringafter shaking
3. washThe organic layer was washed further with saturated aq. NaCl (2×85 mL)
4. dry with materialdried (MgSO4)
5. customRemoval of volatiles in vacuo
6. customgave the product in 93% yield as yellow crystals