反应详情

温度

90 °C

A mixture of 2-brom-3-methylbenzylbromide (25 g, 0.095 mol) and potassium cyanide (16 g, 0.25 mol) in dimethylformamide (100 ml) was stirred at 90° C. for 20 h. The solvent was evaporated under reduced pressure and to the residue were added toluene and water. The organic layer was separated washed with water, separated and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel using methylene chloride as eluent gave 8.8 g (44%) of the title compound.

1. customThe solvent was evaporated under reduced pressure and to the residue
2. additionwere added toluene and water
3. customThe organic layer was separated
4. washwashed with water
5. customseparated
6. customevaporated under reduced pressure
7. customPurification of the residue by column chromatography on silica gel